DANIEL J. RADER, MD
University of Pennsylvania School of Medicine
Dr. Rader is the Cooper-McClure Professor of Medicine and is Professor of Pathology and Pharmacology at the University of Pennsylvania School of Medicine. He is Associate Director of Penn’s Institute for Translational Medicine and Therapeutics and Director of the newly created Translational Research Center. He is also the Director of Preventive Cardiovascular Medicine and Lipid Clinic and the Director of the Lipid-Atherosclerosis Research Unit. Dr. Rader’s basic research laboratory focuses on genetic and pharmacologic regulation of lipoprotein metabolism and atherosclerosis, and he directs a translational research program focusing on human genetics of lipid disorders and atherosclerosis and novel approaches to treatment of dyslipidemia and regression of atherosclerosis. He has a particular interest in HDL metabolism, factors and genes involved in its regulation, the causal nature of the relationship of HDL metabolism to atherosclerosis, and novel approaches to targeting HDL metabolism and reverse cholesterol transport in the treatment, prevention, and regression of atherosclerosis.
Dr Rader received his undergraduate degree from Lehigh University and his medical degree from the Medical College of Pennsylvania. He completed an internship and residency in internal medicine at Yale-New Haven Hospital, followed by a year as a Chief Resident. In 1988 he began a fellowship in lipid metabolism at the Molecular Disease Branch of the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health, and was subsequently appointed to a staff scientist position. He was recruited in 1994 to the University of Pennsylvania.
Dr. Rader is a member of the American Society of Clinical Investigation, a past Established Investigator of the American Heart Association, and a recipient of a Burroughs Wellcome Fund Clinical Scientist Award in Translational Research, a Doris Duke Charitable Foundation Distinguished Clinical Scientist Award, and a Bristol Myers Squibb "Freedom to Discover" Unrestricted Cardiovascular Research Grant. Dr. Rader is an editorial board member of Arteriosclerosis Thrombosis and Vascular Biology, American Journal of Physiology (Endocrinology and Metabolism), Circulation, Circulation Research, Journal of Lipid Research, and Trends in Molecular Medicine. Dr. Rader has authored over 250 peer-reviewed publications, review articles, and book chapters, including chapters on lipoprotein disorders for Harrison’s Principles of Internal Medicine, Topol’s Textbook of Cardiovascular Medicine, and Nelson’s Textbook of Pediatrics. He is a frequently invited speaker nationally and internationally on his basic and translational research in lipoprotein metabolism and atherosclerosis.
JAMES M. McKENNEY, PHARM.D.
James M. McKenney is President and CEO of National Clinical Research in Richmond, Virginia. He is also Professor Emeritus of the School of Pharmacy of Virginia Commonwealth University. Dr. McKenney received his Bachelor of Science degree in pharmacy from the Medical College of Virginia in 1968 and his Doctor of Pharmacy degree in 1972 from Wayne State University of Detroit, Michigan.
Dr. McKenney has been a member of the Coordinating and Executive Committees of the National Cholesterol Education Program since its inception in 1985. He was appointed to the prestigious Adult Treatment Panels II and III, to develop guidelines for the evaluation and treatment of hyperlipidemia, in 1990-2 and 1999-2001 respectively. He was one of the first pharmacists in the nation to be recognized with a Fellowship in the American Society of Hospital Pharmacists in 1988. Dr. McKenney was also the first pharmacist awarded Fellowship in the Council on Arteriosclerosis by the American Heart Association in 1993 and was given the Clinical Practice Award for lifetime contributions made to pharmacy practice by the American College of Clinical Pharmacy in 1996. He currently serves on the Board of Directors and is President of the National Lipid Association; for the NLA, he also serves as Chairman of the NLA Task Force on Statin Safety, a year long effort to examine safety issues with statin therapy.
Dr. McKenney has published over 140 original-research, peer-reviewed papers and many other articles dealing with hypertension, patient compliance and hyperlipidemia. He has been principal or sub-investigator in over 500 clinical trials with cumulative revenues over 24.5 million dollars. He has given over 1600 presentations to professional, scientific and lay audiences during his career.
JAY D. HORTON, MD
Associate Professor of Internal Medicine and Molecular Genetics and the Dr. Robert C. and Veronica Atkins Chair in Obesity and Diabetes Research at the University of Texas Southwestern Medical Center.
Dr. Horton obtained his B.S. and M.D. degrees from the University of Iowa. He completed his internal medicine residency and fellowship in gastroenterology at UT Southwestern Medical Center. Following the gastroenterology fellowship, he completed a Howard Hughes post-doctoral fellowship in the Department of Molecular Genetics at UT Southwestern Medical Center. Dr. Horton is a former PEW scholar and member of the American Society for Clinical Investigation. He serves as a consulting editor for The Journal of Clinical Investigation and The Journal of Lipid Research. Dr. Horton has also served on multiple scientific review committees including the NIH metabolism and INMP study sections, the American Gastroenterological Association Grant Review Panel. Dr. Horton has a clinical interest in nonalcoholic fatty liver disease. His basic scientific interest is in the molecular regulation of fat and cholesterol metabolism.
WILLIS C. MADDREY, MD, MACP, FRCP (London)
Willis C. Maddrey, MD, is Professor of Internal Medicine and is the Executive Vice President for Clinical Affairs at The University of Texas Southwestern Medical Center at Dallas. He is the Adelyn and Edmund M. Hoffman Distinguished Chair in Medical Science at UT Southwestern. Dr. Maddrey received his medical degree from The Johns Hopkins University School of Medicine in Baltimore, Maryland, and completed his residency and Chief Residency on the Osler Medical Service of The Johns Hopkins Hospital. Additional postgraduate work included a fellowship in liver disease with Dr. Gerald Klatskin at Yale University School of Medicine.
From 1970 to 1981, Dr. Maddrey directed the liver unit at The Johns Hopkins University School of Medicine where he was Professor of Medicine and Associate Physician in Chief. From 1982 to 1990, he was Magee Professor and Chairman of the Department of Medicine at Jefferson Medical College in Philadelphia. Dr. Maddrey had been at UT Southwestern since 1990.
Dr. Maddrey is a member of the American Society for Clinical Investigation and the American Gastroenterological Association. He was President of the American Association for the Study of Liver Diseases in 1981. He is a Master of the American College of Physicians and served as its President in 1992-93 and is a Fellow of the Royal College of Physicians of London.
Dr. Maddrey has published extensively in the areas of drug-induced liver disease, chronic viral hepatitis, alcohol-induced liver disease, and primary biliary cirrhosis. He has authored numerous. He has edited or co-edited nine books including Transplantation of the Liver, now in its third edition, and Schiff's Diseases of the Liver, the tenth edition of which was published in November, 2006.
